Anna Cunningham became a popular figure on TikTok while she was undergoing treatment for Ewing sarcoma cancer. She initially joined the app when it was known as musical.ly, and her first video, captioned "Smile," featured Daniel Skye's song "Smile." TikTok featured her videos four times, which helped her reach the 100,000 fan mark by late 2016. Anna attended Basalt High School in Colorado and amassed a significant following with her uplifting content, despite her challenging battle with cancer. In a memorable video where she celebrated her last day of chemotherapy, she used Sia's song "The Greatest."